Fluoroquinolones: then and now.

Evaluation of Resistance to Fluoroquinolones and Its Relationship whit parC Gene Mutation in Klebsiella pneumoniae Clinical Isolates

Background & Objective: Klebsiella pneumoniae has received attention due to a wide range of diseases and antibiotic resistance.The resistance to fluoroquinolones in gram-negative bacteria is often due to chromosomal mutations in the gyr and par genes. This research aimed at investigating the pattern of fluoroquinolone resistance and its relation with a mutation in the parC gene among clinical i...

The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans.

The structures, mechanisms of action and resistance, and spectra of activity of the fluoroquinolones in vitro were considered in the first part of our two-part minireview (48). To place this foregoing information in clinical perspective, we now discuss in this the second part of the minireview the published English literature on the pharmacology, proved and potential clinical uses, and toxiciti...

Minimizing quinolone resistance: are the new agents more or less likely to cause resistance?

The introduction of oral antimicrobial agents with broad-spectrum activity extending to methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and other multiply antibiotic-resistant pathogens made the fluoroquinolones an attractive choice for empirical therapy for an extensive range of conditions. As a consequence there has been heavy and indiscriminate use of these agents ...

Detection of Efflux Pumps Genes in Fluoroquinolones Resistant and Sensitive strains of Escherichia coli isolated from Patients with Urinary Tract Infection in Qom

Abstract Background and Objectives: Efflux pumps are one of the main mechanisms for antibiotic resistance in Escherichia coli strains. The aim of this study was to investigate the relationship between 5 different efflux pump genes; acrA, acrB, emrA, emrB and mdtk and fluoroquinolone resistance in E.coli Isolated from patients with urinary tract infections in Qom. Methods: In this descriptive cr...

Isolation, Identification and in vitro Susceptibility of Avian Escherichia coli to Selected Fluoroquinolones